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Scientific Research Finds the Most Effective Nutrients for Combating Arthritis

A look at the Clinical Trials and Research for Glucosamine Sulfate, Chondroitin Sulfate, Bromelain, Curcumin, MSM, Ginger for Arthritis

Joint-Repair-Arthritis-Scientific

The Problem

Arthritis is an inflammation of one or more of your joints that affects more than 100 million people (33% of the population) in the United States, but the exact cause is still relatively unknown. Symptoms are variable and can differ from day to day and from one person to another, making it extremely difficult to predict in advance the manifestations one will experience while combating the condition. However, the majority of people will struggle with the following; Joint Pain, Fatigue, Joint Tenderness, Joint Swelling, Joint Redness, Joint Stiffness, Joint Deformity, Loss of Joint Range of Motion, Limping and Joint Warmth.

Unfortunately, there is no current cure for Arthritis and the people dealing with the condition can only hope to manage their symptoms. However, there are steps that can be taken to lower the incidence of these symptoms. While most doctors would suggest a treatment that consists of conventional medicine, there is a much more natural course that can be taken.

Read on to learn more about the research, for each nutrient, which has strong scientific backing for being statistically significant methods of helping alleviate Arthritis.

The Solutions

1. Glucosamine Sulfate

Glucosamine Sulfate is a kind of amino acid that possesses numerous positive therapeutic benefits, such as the ability to improve the following; cardiovascular function, anti inflammatory responses, eye health, skin health and complexion, bladder health, bone health, reproductive health, iron absorption, joint health and muscle strength. According to the NIH, most of the United States population ingest far too little Glucosamine Sulfate in their daily food intake.

A Scientific Study

The Conclusion

Results of the patients’ self-evaluations and the physician's’ global evaluations indicated that the glucosamine treatment produced noticeable improvements in symptoms.

The Method

The purpose of this study was to examine whether glucosamine has an antirheumatic effect in a randomized placebo-controlled study.The subjects were 51 rheumatoid arthritis (RA) patients: 25 patients in the glucosamine group and 26 patients in the placebo group. Glucosamine hydrochloride at a daily dose of 1,500 mg and placebo, respectively, were administered for 12 weeks along with conventional medication.

The Results

While significant improvement was not found in joint counts and in the rate of ACR20 responders, the face scale and a visual analogue scale pain were significantly in favor of the glucosamine group. ESR and CRP levels did not change, but serum MMP-3 levels decreased in the glucosamine group.

Link to Study

 

2. Chondroitin Sulfate

Chondroitin Sulfate is a kind of amino acid that possesses numerous positive therapeutic benefits, such as the ability to improve the following; cardiovascular function, anti inflammatory responses, eye health, skin health and complexion, bladder health, bone health, reproductive health, iron absorption, joint health and muscle strength. According to the NIH, most of the United States population ingest far too little Chondroitin Sulfate in their daily food intake.

A Scientific Study

The Conclusion

These results demonstrate that chondroitin sulfate is effective for reducing the rate of decline in minimum joint space width in patients with knee OA.

The Method

A published meta-analysis of randomized controlled trials was updated to include data from one new trial and final data from a second trial both published recently in peer-reviewed literature. This meta-analysis was limited to three RCTs of 2-year duration. Data were pooled using a fixed effects model as there was no evidence of important heterogeneity.

The Results

Pooled results demonstrated a small significant effect of chondroitin sulfate on the reduction in rate of decline in minimum joint space width of 0.13 mm [95% confidence interval (CI) 0.06, 0.19] (P = 0.0002) that corresponded to an effect size of 0.23 (95% CI 0.11, 0.35) (P = 0.0001).

Link to Study

 

3. Bromelain

Bromelain (Ananas) is a kind of amino acid that possesses numerous positive therapeutic benefits, such as the ability to improve the following; cholesterol levels, anti inflammatory responses, immune response, hormonal balance, skin health and complexion, injury recovery time, respiratory function, metabolism, joint health and digestion. According to the NIH, most of the United States population ingest far too little Bromelain in their daily food intake.

A Scientific Study

The Conclusion

The improvement of joint pain was clinically relevant in patients treated with AINAT for both acute and chronic OA pain. Considering its excellent tolerance profile, the tested complex of 3 plant extracts with anti inflammatory properties may be a valuable and safe alternative to NSAIDs in patients suffering from degenerative joint diseases.

The Method

A multicenter, observational, prospective, open-label survey was conducted in 8 rheumatology centers. The study included 2 groups, 1 group with participants suffering from chronic osteoarthritis (OA) pain and 1 group suffering from acute OA pain. A total of 42 patients (36 women; mean age = 67 y) suffering from acute or chronic, degenerative spine or joint pain participated. Two 650-mg capsules of AINAT were administered 3 ×/d to patients with acute pain and 2 ×/d to patients with chronic pain.

The Results

At baseline, the VAS pain score (standard deviation) was 69.1 mm (15.4) and 68.0 mm (18.2) for patients with acute and chronic pain, respectively. At the endpoint, the scores decreased to 42.1 mm (21.1) and 37.8 mm (25.9), respectively. This reduction of pain, as a percentage as well as an absolute value, corresponds to the required definition of MCII, particularly in patients with chronic joint pain. At the endpoint, most of the patients in both groups reached the level of pain defined as the PASS. No withdrawals occurred due to treatment side effects.

Link to Study

 

4. Curcumin

Curcumin is a kind of herb that possesses numerous positive therapeutic benefits, such as the ability to improve the following; cardiovascular function, anti inflammatory responses, cholesterol levels, mood levels, cognitive abilities, skin health and complexion, mental health, illness recovery, joint health and digestion. According to the NIH, most of the United States population ingest far too little Curcumin in their daily food intake.

A Scientific Study

The Conclusion

The study provides the first evidence for the safety and superiority of curcumin treatment in patients with active RA, and highlights the need for future large-scale trials to validate these findings in patients with RA and other arthritic conditions. Copyright © 2012 John Wiley & Sons, Ltd.

The Method

This pilot clinical study evaluated the safety and effectiveness of curcumin alone, and in combination with diclofenac sodium in patients with active rheumatoid arthritis (RA). Forty-five patients diagnosed with RA were randomized into three groups with patients receiving curcumin (500 mg) and diclofenac sodium (50 mg) alone or their combination. The primary endpoints were reduction in Disease Activity Score (DAS) 28. The secondary endpoints included American College of Rheumatology (ACR) criteria for reduction in tenderness and swelling of joint scores.

The Results

Patients in all three treatment groups showed statistically significant changes in their DAS scores. Interestingly, the curcumin group showed the highest percentage of improvement in overall DAS and ACR scores (ACR 20, 50 and 70) and these scores were significantly better than the patients in the diclofenac sodium group. More importantly, curcumin treatment was found to be safe and did not relate with any adverse events.

Link to Study

 

5. MSM

MSM (Methyl Sulfonyl Methane) is a kind of mineral that possesses numerous positive therapeutic benefits, such as the ability to improve the following; blood sugar regulation, anti inflammatory responses, bone health, toxin reduction, skin health and complexion, energy levels, flexibility, illness recovery, wound healing and joint health. According to the NIH, most of the United States population ingest far too little MSM in their daily food intake.

A Scientific Study

The Conclusion

These results suggest that appropriate intake of MSM is possibly effective in OA model mice.

The Method

This study examined the effects of MSM on cartilage formation in growing rats (G) and cartilage degradation in STR/Ort mice (A), an accepted human osteoarthritis (OA) model. For cartilage formation study, 6-week-old growing male Wister rats were assigned to four groups to receive a control or MSM-containing diet. To examine the efficacy of MSM on the cartilage of OA model mouse, 10-week-old male STR/OrtCrlj mice were assigned to three groups to receive a control or MSM-containing diet. The dosages used were amounts equal to the recommended supplements for humans [0.06 g/kg body weight (BW)/day: MSM1G and MSM1A], 10 fold higher (0.6 g/kg BW/day: MSM10G and MSM10A), and 100 fold higher (6 g/kg BW/day: MSM100G).

The Results

Intake of MSM for 4 weeks did not affect cartilage formation in the knee joint in growing rats. Body, liver, and spleen weight in the MSM100G group were significantly lower than those in the control group. Intake of MSM for 13 weeks decreased degeneration of the cartilage at the joint surface in the knee joints in STR/Ort mice in a dose-dependent manner.

Link to Study

 

6. Ginger

Ginger (Zingiber Officinale) is a kind of herb that possesses numerous positive therapeutic benefits, such as the ability to improve the following; blood sugar regulation, anti inflammatory responses, cholesterol levels, nausea, cognitive abilities, hormonal balance, reproductive health, joint and muscle health, pain reduction and digestion. According to the NIH, most of the United States population ingest far too little Ginger in their daily food intake.

A Scientific Study

The Conclusion

In conclusion, these data document a very significant joint-protective effect of these ginger samples and suggest that nongingerol components are bioactive and can enhance the antiarthritic effects of the more widely studied gingerols.

The Method

Therefore, the ability of a well-characterized crude ginger extract to inhibit joint swelling in an animal model of rheumatoid arthritis, streptococcal cell wall-induced arthritis, was compared to that of a fraction containing only gingerols and their derivatives.

The Results

Both extracts were efficacious in preventing joint inflammation. However, the crude dichloromethane extract, which also contained essential oils and more polar compounds, was more efficacious (when normalized to gingerol content) in preventing both joint inflammation and destruction.

Link to Study

 

The Takeaway

To summarize, in the article, we have gone through 6 supplements which were determined as extremely effective in combating Arthritis. The basis of this assertion comes solely from scientific research, clinical trials, and studies published in respectable journals. While some of these nutrients can be obtained from foods alone, it is strongly recommended, for those suffering from Arthritis, to take a regular daily dose of supplementation to ensure sufficient intake to meet clinical needs.

However, when taking so many different supplementations it is critical to take specific dosages in order to avoid damaging what you're trying to fix. It is for this exact reason that SpecifiCare’s expert Libby Greenberg, ND has created a specific formula for people with Arthritis. By taking the formula, you raise your chances of starting to feel better and experience reduced Arthritis related symptoms.

 

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